The first copper(i) and palladium(ii) complexes containing monastrol analogs, 4-thioxo[1,3,5]oxadiazocine derivatives, have been synthesized. The complexes demonstrated significant antibacterial activity in contrast to free heterocyclic thiones.

Cyclic thioureas, which are represented by 4-thioxo [1,3,5] oxadiazocines and pyrimidine-2-thiones, are the objects of intensive research in scientific groups around the world. Coordination compounds based on them are still poorly studied, despite the intriguing variety of their biological properties. In this work, copper(I) chloride was chosen as the starting salt for the preparation of the target coordination compounds 4-thioxo [1,3,5] oxadiazocines and pyrimidine-2-thiones.