Hyperbilirubin in newborns requires prompt and prompt intervention. A newborn is categorized as hyperbilirubun if there is an increase in the total serum bilirubin level to> 5 mg / dl. Treatment for lowering bilirubin levels can be done medically and non-medically. The many choices of interventions to reduce bilirubin levels in newborns make researchers feel the need to conduct a systematic literature review. Literature search was performed on reputable data based on google scholar, PubMed, Proquest, Ebsco and Medline using the keyword "Intervention AND to reduce bilirubin levels AND Newborn". In the literature search stage, the researcher found 11,959 articles. The literature collection was carried out using the Joana Briggs Institute Critical Appraisal tools for analytical cross-sectional and analytical case control. The literature selection was carried out using PRISMA: Preferred Reporting Item For Systematic Review and Meta-Analysis. At the stage of selecting literature the researcher found 100 suitable articles. Literature analysis and synthesis were performed using matrix review tables and matrix synthesis tables. In the literature synthesis stage, the researcher found 10 suitable articles. The results of the systematic literature review show that the intervention of infant massage, photo therapy, early initiation of breastfeeding and the use of Billy Blanket can reduce the total serum bilirubin levels of newborns and prevent kernicterus. Infant massage interventions, photo therapy, early initiation of breastfeeding, breastfeeding every 2 hours and the use of Billy Blanket can significantly reduce total serum bilirubin levels and percutaneous bilirubin levels. Health workers need to increase their competence to select and determine the type of intervention that can be used to reduce the serum bilirubin level of newborns appropriately.