The soundness of a bank can be seen with several indicators. Some of the indicators are the main indicators on which the valuation is based. Financial statement analysis can help users of financial statements in assessing the financial condition of the bank. In assessing the bank's financial condition, some ratios are Capital Adequacy Ratio (CAR), Non Performing Loan (NPL), Net Interest Margin (NIM), Operating Income Operating Cost (BOPO) and Loan to Deposit Ratio (LDR) as independent variable. The purpose of this study to see and test how the influence of these ratios on bank profitability as a dependent variable. The research was conducted at a banking company listed on the Indonesia Stock Exchange. The samples of this research are 20 banks listed on Indonesia Stock Exchange in 2012 -2016. Test data in this research using E-Views 6 statistical application, the result of this research shows that CAR has negative and significant effect on profitability, NPL has negative and insignificant on profitability, NIM positively and significantly affect profitability, BOPO has a negative and significant effect on profitability and LDR have negative and insignificant effect on profitability.