The title ketocarboxylic acid, synthesized from the anti‐inflammatory clocortolone pivalate, crystallizes as C21H23ClO4·C6H12O, with one molecule of steroid and one of 3,3‐dimethylbutanone per asymmetric unit. The carboxyl group is highly ordered and the steroid molecules form translational carboxyl‐to‐ketone hydrogen‐bonding catemers [O...O = 2.682 (3) Å and O—H...O = 158°] that utilize the 3‐ketone group, with one chain proceeding in the [110] direction and the other in the [10] direction. One close intermolecular C—H...O=C contact is present, which involves the solvent O atom, but neither it nor the Cl atom nor the 11‐ketone group play any role in the classical hydrogen bonding.