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Giant cell lichenoid dermatitis is a recently described dermatosis thought to be an unusual lichenoid drug eruption. It is characterized by a generalized, pruritic, papulosquamous eruption sparing palms, soles, face and mucous membranes. Histopathologic findings include areas of epidermal hyperplasia and atrophy with focal vacuolar alteration of the basal layer, exocytosis and cytoid body formation. The dermis contains a band-like, mononuclear cell infiltrate at the dermoepidermal junction with admixed eosinophils, plasma cells and large multinucleate cells. The histologic differential diagnosis includes infectious processes, sarcoidosis, lichen nitidus, lupus erythematosus and lichen planus. We report 3 patients with giant cell lichenoid dermatitis, one of whom was subsequently diagnosed as having sarcoidosis. Because giant cell lichenoid dermatitis may resemble sarcoidosis both clinically and histologically, and because cutaneous sarcoid is often associated with systemic involvement, the diagnosis of sarcoid should be strongly considered in patients with giant cell lichenoid dermatitis.

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This paper deals with a comparison of the antibody-evoking capacities (in rabbits) of weakly encapsulated and of strongly encapsulated cells of Cryptococcus neoformans and with the influence of the number of the fungus cells (amount of vaccine) upon the strength and the promptness of the antibody response. The data on these two points contribute toward a better understanding of the immunogenic properties of this fungus and, in addition, present an instance in which antibodies reactive with the large capsules of strongly encapsulated forms of a species were produced more effectively by immunization with weakly encapsulated forms than by immunization with the strongly encapsulated forms of the species. The prevailing impression that Cryptococcus antiserums are difficult or inconvenient to produce has come from the fact that a number of workers failed with all strains tried, others failed with some strains although succeeding with others, and all who have reported the production of reasonably potent antiserums have employed prolonged series of injections over periods ranging from 64 to 12 weeks. The literature consists of the papers of Stoddard and Cutler