Objectives Gummetal® (Maruemu Works, Osaka, Japan), a new orthodontic wire material successfully used in clinical applications since 2006, is biocompatible and exhibits exceptionally high elasticity, nonlinear elastic behavior, plasticity and strength. Systematic comparisons of friction behavior are lacking; thus, the friction of Gummetal® in the binding modus was compared to commonly used low friction wires. Materials and methods In vivo tests were run with Gummetal®, CoCr (cobalt-chromium Elgiloy®, Rocky Mountain Orthodontics, Denver, CO, USA), β‑Ti (β-Titanium TMA®, Ormco, Orange, CA, USA), NiTi (nickel–titanium, NiTi-SE, Dentalline, Birkenfeld, Germany), and stainless steel (SS; Ref. 251-925, 3M Unitek, Monrovia, CA, USA) [dimensions: 0.014 inch (0.35 mm), 0.016 inch (0.40 mm), 0.016 × 0.022 inch (0.40 × 0.56 mm), and 0.019 × 0.025 inch (0.48 × 0.64 mm)—β-Ti not available in the dimension 0.014 inch]. These were combined with Discovery® (Dentaurum, Ispringen, Germany), Micro Sprint® (Forestadent, Pforzheim, Germany), Clarity™ (3M Unitek), and Inspire Ice™ (Ormco) and slots in the dimension 0.022 inch (0.56 mm) and, except for the 0.019 × 0.025 inch wires, in the dimension 0.018 inch (0.46 mm). They were ligated with a 0.010 inch (0.25 mm) steel ligature (Smile Dental, Ratingen, Germany). Brackets were angulated by applying a moment of force of 10 Nmm against the wire, which was pulled through the slot at 0.2 mm/s. Results In 660 tests using 132 bracket–wire combinations, friction loss for Gummetal® was comparable to and, in a few combinations with Micro Sprint®, significantly lower (p < 0.05) than SS and CoCr. The friction for Gummetal® was significantly lower (p < 0.05) than NiTi, and β‑Ti. In some bracket–wire combinations, lower friction was found with round wires compared to rectangular wires, except for the combination with Inspire Ice™, which was higher but not significant. Slot size did not have a significant effect on friction in most combinations. Conclusion The low friction associated with Gummetal® wires during arch-guided tooth movement will be a valuable addition to the armamentarium of orthodontists.