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Background: As the gold-standard test to quantify Insulin resistance (IR) involves intravenous insulin loading and repeated blood glucose monitoring, many indexes have been developed for IR assessment for convenience. Objective: To evaluate the agreement of the Single Point Insulin Sensitivity Estimator (SPISE) by comparing it with the homeostasis model assessment of (HOMA-IR) in identifying IR. Method: Data came from the ongoing LIMACHE BIRTH COHORT. 1948 individuals (aged 22 to 28 years) participants were studied. We performed an agreement plot, called a Bangdiwala's Observer Agreement to evaluate patterns in departures from agreement in ordinal categorical variables. Results: According to the Bangdiwala_Weighted statistics, we found that the agreement between both indexes was 0.14, this value would be considered a slight agreement. Thus, we found bias in the marginal distributions, we noticed that the SPISE has a bias towards the central quintiles of the index. Conclusions: The identification of insulin resistance in young adult individuals by the SPISE index has slight agreement with HOMA-IR. Therefore, caution would be taken when considering SPISE index among young Chilean adults.