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The system combining the tetraphosphine cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane (Tedicyp) and [Pd(C3H5)Cl]2 has been found to be a very active catalyst for the cross-coupling of aryl bromides with alkyl- or arylzinc derivatives (Negishi reaction). A variety of aryl bromides react in good yields and high turnover numbers (TONs) (up to 800 000) with diethylzinc, n-butylzinc bromide, or n-hexylzinc bromide in the presence of 0.1−0.0001 mol % catalyst in most cases.

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