Motion capture systems are recognized as the gold standard for joint angle calculation. However, studies using these systems are restricted to laboratory settings for technical reasons, which may lead to findings that are not representative of real-life context. Recently developed commercial and home-made inertial measurement sensors (M/IMU) are potentially good alternatives to the laboratory-based systems, and recent technology improvements required a synthesis of the current evidence. The aim of this systematic review was to determine the criterion validity and reliability of M/IMU for each body joint and for tasks of different levels of complexity. Five different databases were screened (Pubmed, Cinhal, Embase, Ergonomic abstract, and Compendex). Two evaluators performed independent selection, quality assessment (consensus-based standards for the selection of health measurement instruments [COSMIN] and quality appraisal tools), and data extraction. Forty-two studies were included. Reported validity varied according to task complexity (higher validity for simple tasks) and the joint evaluated (better validity for lower limb joints). More studies on reliability are needed to make stronger conclusions, as the number of studies addressing this psychometric property was limited. M/IMU should be considered as a valid tool to assess whole body range of motion, but further studies are needed to standardize technical procedures to obtain more accurate data.

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by polyglutamine expansions in the amino-terminal region of the huntingtin (Htt) protein. At the cellular level, neuronal death is accompanied by the proteolytic cleavage, misfolding and aggregation of huntingtin. Abnormal hyperphosphorylation of tau protein is a characteristic feature of a class of neurodegenerative diseases called tauopathies. As a number of studies have reported tau pathology in HD patients, we investigated whether HD pathology may promote tau hyperphosphorylation and if so tackle some of its underlying mechanisms. For that purpose, we used the R6/2 mouse, a well-characterized model of HD, and analyzed tau phosphorylation before and after the onset of HD-like symptoms. We found a significant increase in tau hyperphosphorylation at the PHF-1 epitope in pre-symptomatic R6/2 mice, whereas symptomatic mice displayed tau hyperphosphorylation at multiple tau phosphoepitopes (AT8, CP13, PT205 and PHF-1). There was no activation of major tau kinases that could explain this observation. However, when we examined tau phosphatases, we found that calcineurin/PP2B was downregulated by 30% in pre-symptomatic and 50% in symptomatic R6/2 mice, respectively. We observed similar changes in tau phosphorylation and calcineurin expression in Q175 mice, another HD model. Calcineurin was also reduced in Q111 compared with Q7 cells. Finally, pharmacological or genetic inhibition of endogenous calcineurin was sufficient to promote tau hyperphosphorylation in neuronal cells. Taken together, our data suggest that mutant huntingtin can induce abnormal tau hyperphosphorylation in vivo, via the deregulation of calcineurin.

Background: Workplace adaptation is the preferred method of intervention to diminish risk factors associated with the development of work-related shoulder disorders. However, the majority of the workplace assessments performed are subjective (e.g., questionnaires). Quantitative assessments are required to support workplace adaptations. The aims of this study are to assess the concurrent validity of inertial measurement units (IMUs; MVN, Xsens) in comparison to a motion capture system (Vicon) during lifting tasks, and establish the discriminative validity of a wireless electromyography (EMG) system for the evaluation of muscle activity. Methods: Sixteen participants performed 12 simple tasks (shoulder flexion, abduction, scaption) and 16 complex lifting tasks (lifting crates of different weights at different heights). A Delsys Trigno EMG system was used to record anterior and middle deltoids’ EMG activity, while the Xsens and Vicon simultaneously recorded shoulder kinematics. Results: For IMUs, correlation coefficients were high (simple task: >0.968; complex task: >0.84) and RMSEs were low (simple task: <6.72°; complex task: <11.5°). For EMG, a significant effect of weight, height and a weight x height interaction (anterior: p < 0.001; middle: p < 0.03) were observed for RMS EMG activity. Conclusions: These results suggest that wireless EMG and IMUs are valid units that can be used to measure physical demand in workplace assessments.