The diversity of these vesicles in terms of size, lamellarity, and internal organization advocate their important role during lipid digestion in the gastrointestinal milieu.

An array of simulated intestinal fed-state fluids, where phosphatidylcholine (PC) was replaced by lysophosphatidylcholine (LPC) and cholesterol (Chol) was added, were visualized with Cryogenic Transmission Electron Microscopy (Cryo-TEM). Micelles were the dominating structural features, emphasizing the micellar-forming characteristics of LPC. Upon increase of the monoglyceride (MG) level, unilamellar vesicles and multivesicular structures were formed. These findings suggest the solubilization of poorly soluble drugs might be affected by the intermediate colloidal phases produced in the gastrointestinal tract.