The combination of bioresorbable and biodegradable hydrophilic polysaccharides with biodegradable hydrophobic polyester chains to form totally biodegradable, nonionic brushlike amphiphilic graft copolymers useful as surfactants has been investigated. In fact, a totally controlled and original three-step procedure is described which gives access to a wide range of poly(ε-caprolactone)-grafted dextran copolymer compositions. It consists of the reversible protection of the hydroxyl groups of the polysaccharide backbone by silylation, followed by the ring-opening polymerization of ε-caprolactone initiated by the free remaining hydroxyl groups of the partially silylated dextran in the presence of aluminum and tin-based catalysts. The last step relies upon the removal of silylating groups under mild acidic conditions yielding the desired amphiphilic graft copolymers.

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Coupling atom transfer radical polymerization (ATRP) and coordination‐insertion ring‐opening polymerization (ROP) provided a controlled two‐step access to polymethacrylate‐graft‐polyaliphatic ester graft copolymers. In the first step, copolymerization of methyl methacrylate (MMA) and 2‐hydroxyethyl methacrylate (HEMA) was carried out at 80 °C at high MMA concentration by using ethyl 2‐bromoisobutyrate and [NiBr2(PPh3)2] as initiator and catalyst, respectively. Kinetic and molar masses measurements, as well as 1H NMR spectra analysis of the resulting poly(MMA‐co‐HEMA)s highlighted the controlled character of the radical copolymerization, while the determination of the reactivity ratios attested preferential incorporation of HEMA. The second step consisted of the ROP of ε‐caprolactone or L,L‐dilactide, in THF at 80 °C, promoted by tin octoate (Sn(Oct)2) and coinitiated by poly(MMA‐co‐HEMA)s obtained in the first step. Once again, kinetic, molar mass, and 1H NMR data demonstrated that the copolymerization was under control and started on the hydroxyl functions available on the poly(MMA‐co‐HEMA) multifunctional macroinitiator.Comparison of the SEC traces for the poly(MMA‐co‐HEMA) macroinitiator P2 (line only), the polymethacrylate‐g‐PLA copolymer C2 (line marked by ○), and the polymethacrylate‐g‐PLA C3 (line marked by ▵).magnified imageComparison of the SEC traces for the poly(MMA‐co‐HEMA) macroinitiator P2 (line only), the polymethacrylate‐g‐PLA copolymer C2 (line marked by ○), and the polymethacrylate‐g‐PLA C3 (line marked by ▵).