Catalytic hydrosilation of 1-(trimethylsilyl)-1-buten-3-yne (1) with three kinds of hydrosilanes (HSiMePh2, HSiMe2Ph, and HSiEt3) in CDCl3 at 30 °C in the presence of a catalytic amount of RuHCl(CO)(PPh3)3 (2) gave five types of reaction products:  (1E,3E)-CH(SiR3)CHCHCHSiMe3 (3), R3SiCH2CHCHCH2SiMe3 (4), R3SiCHCCHCH2SiMe3 (5), (1Z,3E)-CH(SiR3)CHCHCHSiMe3 (6), and R3SiC⋮CCHCHSiMe3 (7). Detailed investigations on the stoichiometric reactions of intermediate ruthenium species provided definitive evidence for the catalytic mechanism comprised of two catalytic cycles, the Chalk−Harrod cycle A and the modified Chalk−Harrod cycle C, and their interconnecting processes B and D. Product 3 is formed by the insertion of 1 into the Ru−H bond of 2 followed by the reaction of the resulting terminal dienyl complex Ru(CHCHCHCHSiMe3)Cl(CO)(PPh3)2 (8) with hydrosilane. The latter process regenerates 2 and the sequence of reactions proceeds catalytically (cycle A). The reaction of 8 with hydrosilane is accompanied by a side reaction giving Ru(SiR3)Cl(CO)(PPh3)2 (9) and CH2CHCHCHSiMe3 (10), and the latter is further converted to 4 by hydrosilation (process B). Silyl complex 9 thus generated in the system is the key intermediate for catalytic cycle C. Thus the insertion of 1 into the Ru−SiR3 bond of 9 via a formal trans-addition process forms an internal dienylruthenium complex Ru[C(CHSiR3)CHCHSiMe3]Cl(CO)(PPh3)2 (11), which reacts with hydrosilane to give 5 and 6 and to regenerate 9. A part of 11 also undergoes β-hydrogen elimination to give a dehydrogenative silation product 8 and hydride complex 2. Complex 2 thus formed resumes catalytic cycle A (process D). The catalytic intermediates 8, 9, and 11 were identified by NMR spectroscopy and/or elemental analysis. Factors controlling the catalytic cycles are discussed on the basis of the experimental observations.

Binuclear ligands possessing two discrete multidentate N-heterocyclic podand coordination sites connected by a flexible propylene spacer and a rigid m-xylene spacer were synthesized. Treatment of the binuclear ligands with Ni(Oac)2 afforded the bimetallic nickel(II) complexes with two discrete nickel centers. The single-crystal X-ray structure determination of the bimetallic nickel(II) complex with a propylene spacer revealed a little distorted square planar geometry at each nickel center.

A quantitative structure-activity relationship formulated for 59 4-anilinopyrimidines inhibiting reserpine-induced ptosis was applied to the design of new , more active, antidepressant compounds. The utility of correlation equations in designing new congeners is discussed and the designed compounds synthesized show the most active group of the anilinopyrimidines .

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