Introduction: The successful restoration of damaged tissue requires a complicated, dynamic process called wound healing, which is supported by a wide range of cellular activities. Natural materials generated from medicinal plants have been identified, and their therapeutic potential evaluation has resulted in the development of novel, affordable medicines that can be used to treat a variety of illnesses, including chronic wounds, with limited side effects. Aims and Objectives: This study aimed to assess the wound-healing property of Glycyrrhiza Glabra (Athimathuram) plant extracts by using an in vitro scratch assay test, as well as to evaluate their cellular toxicity. Materials and Methods: Using the Soxhlet device, ethanolic extraction of the plant material was done, and the cytotoxicity of the extract on the Vero cell line was examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. One of the most often utilized mammalian in vitro cell lines in research was Vero cells. To assess the wound healing properties of G. glabra plant extract, an in vitro scratch assay was used, and their potential mechanisms of action were examined. Results: Even at higher concentrations, the MTT assay showed that G. Glabra plant extracts had no cytotoxic effects on the cells. In vitro scratch assay showed that the healing process of the cell line was increased by 23.33% when compared with the controlled cell lines. Conclusion: Our research demonstrated that G. glabra has in vitro wound healing capabilities. As a result, G. glabra can be suggested as a possible source of compounds that treat wounds.

No abstract

Feeding problem remains a common problem among preterm neonates. An experimental study was undertaken to assess the effect of oromotor stimulation on feeding and sucking performance of preterm neonates admitted in selected hospital, west Bengal. Quasi experimental time series design was adopted. From the population of preterm neonates 60 samples (30 in experimental group and 30 in control group) were selected by non-probability purposive sampling. After selection, initially the baseline data was collected using a record analysis proforma. On the 1st day sucking and feeding performance scoring was done before giving the oromotor stimulation to ascertain the homogeneity of the experimental and control group. After that in two consecutive feeding, oromotor stimulation was given to the neonates in experimental group before 15 minutes of the feeding. The intervention was given to the neonates in experimental group for the next two days, twice only in two consecutive feeding. Neonates in control group received routine care. Sucking and feeding performance scoring was done in both groups using a standardized non-nutritive sucking scoring scale and a validated and reliable early feeding performance scale. The result showed that there is significant difference in sucking performance (t=3.60, p<0.05) and feeding performance (t=3.78, p<0.05) among experimental and control group in final observation. It can be concluded that oromotor stimulation is effective to improve the feeding and sucking abilities of preterm neonates. In the neonatal care units, nurses can provide oromotor stimulation to improve feeding and sucking abilities of the preterm neonates. Keywords: Feeding, Sucking, Performance, Preterm, Oromotor stimulation, Neonates, Preterm neonates.