Introduction: Female Breast cancer is the second leading cause of cancer-related deaths in the U.S. While the incidence rate is lower in Hispanic-Black, the mortality rate is higher compared to Non-Hispanic White. This study investigates the trends of incidence and mortality rate of breast cancer in the U.S.: 2000-2016. It further explores the racial disparities between these two races. Method: Data for four age groups (15 -39 yrs, 40 -64 yrs, 65 -74 yrs, 75+ yrs) of Hispanic-Black and Non-Hispanic White women for breast cancer were extracted from SEER; age-adjusted rate (U.S. 2000 standard population). Primary trend analysis was done with PyCharm 2020.3.3. (line charts) and regression models to check any significant increase or decrease over the years were done with JoinPoint 4.8.0.1 (APC, 95% CI, significant p-value: <0.05). Result: Incidence rate is higher in Non-Hispanic White women, whereas mortality rate is higher in Hispanic Black. The 40 -64 yrs age groups showed an increase in incidence rate for Hispanic Black women, whereas an decrease for White women. The least vulnerable group, 15 -39 yrs age showed an increase in incidence rate in Non-Hispanic White women. The mortality rate was declining overall for both races. Conclusion: Disparities in oncologic healthcare, insurance system and socio-economic factors are possibly responsible for the higher mortality in Black American women. Improvements in these factors may reduce racial differences.