Background: Informed consent (IC) is a critical step in ensuring that patients understand implications of their treatment decisions. Materials and Methods: It is observational cross-sectional study. Non probability purposive sampling was used to collect data from different surgical units. Adult postsurgical patients were questioned using a standardized questionnaire between the first- and fifth-day following surgery in two general hospitals in Sindh province (Hyderabad and Jamshoro). Data was analyzed using SPSS and Microsoft excel. Results: A total of 78% of individuals who claimed to have read it found informed consent to be easy to understand. Less than half of patients thought information brought them some emotional solace, while 23.2% of patients reported feeling more anxious after hearing information. This study suggests enhancing the process of obtaining consent forms by including additional information and avenues for discussion on written documents rather than relying solely on verbal communication. Conclusion: Patients under age of sixty and patients who had completed more schooling tended to read written informed consent forms more frequently. Orally communicated pre-operative information suited patients' requirements better than written informed consent. Surgeon needs to get informed permission from patient and inform them about operation type, potential consequences and other treatment options. Keywords: Informed consent, Medical Ethics, Surgery, Hospital, Surgeons, Health, Sindh.

Objectives: To determine the clinical presentation of patients of Carcinoma of Rectum and Different modalities of treatment. Methodology: This was a Prospective observational study conducted in from May 2019 to April 2021 at Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro, Sindh, Pakistan. The study comprises 50 patients. All were admitted from Outpatient Department (OPD).  All patients were evaluated fully after history & Clinical examinations Digital Rectal Examination (DRE) with Proctoscope and specific investigations of, Stool DR, Fecal occult blood, ultra sound of abdomen and pelvis, Sigmoidoscopy, Colonoscopy with biopsy, Barium enema, C T Scan of Abdomen, chest & pelvis, MRI Abdomen &Pelvis, PECT Scan, Anorectal or Endoluminal Ultra sound, Tumor Marker CEA, Monoclonal Antibodies, LDH level, LFT for liver. and X-  Ray chest PA view. Complete blood picture (CBC) Blood urea, sugar, serum electrolyte, HBSAG, HCV, & HIV, COVID -19, LFT, PT, APTT, INR and ECG for fitness purpose and general assessment. Results: In this study 50 patients of carcinoma of Rectum were reported. The maximum number of patients were in age group between 12 to 80 years. Out of 50 patient, 15  patients were presented with Altered Bowel habit (Constipation and Diarrhea)  & Spurious Morning Diarrhea , 13  patients  were presented with Altered Bowel habit (Constipation & Diarrhea)  Spurious Morning Diarrhea ,With Bleeding per rectum. Out of 50 patients   15 patients were diagnosed stage 1 ,13 patients were diagnosed stage 11, 9 patients were diagnosed stage 111, 13 patients were diagnosed stage 1V.  Out of 50 patients 28 patients were treated with anterior resection, 15 patients initially treated with New adjuvant therapy followed by patients were treated APR with TME, immunotherapy, gene therapy.  4 patients were treated initially diversion colostomy, then Neo adjuvant therapy, 3 patients were treated laparotomy, colostomy, hart men procedure, Chemo radio therapy, Immunotherapy, Gene therapy. Conclusion: Carcinoma of Rectum is a common problem all over the world. Patients of carcinoma rectum can present diarrhea, constipation, bleeding per rectum, spurious morning diarrhea if not diagnose, and treat the patient in early stage, patients live style will be complicated.