A new Cu (II) complex with Schiff base ligand 2-hydroxy-2-methyl propiophenone sulfaguanidine (HMPSG) has been prepared in alcoholic medium and investigated by elemental analysis and spectroscopic methods. The ligand and its Cu (II) complex were subjected to cyclic voltammetric studies using glassy carbon electrode with variable scan rate at various pH levels. The electrochemical studies show single Irreversible reduction wave for ligand while quasi- reversible wave for its Cu (II) complex. For comparative studies, electrochemical measurements were carried out in different polarity solvents. Various kinetic variables such as charge transfer coefficient (αn), diffusion coefficient (D01/2) rate constant (K0f,h) were also determined from cyclic voltammograms measurement. Further, ligand and its Cu (II) complex were analyzed for antimicrobial studies.

The present paper investigated the electrochemical behaviour of Schiff base and its zinc complex at a working electrode by cyclic voltammetry technique. In the phosphate and Britton-Robinson buffers, the electrochemical study of Schiff base was performed within various pH values 5-9. Cyclic voltammograms of the examined Schiff base exhibited irreversible and diffusion controlled waves at different sweep rates, which is associated with the two electron reduction process of azomethine group. The symmetry transfer coefficient (αn), the diffusion coefficient (D01/2) and rate constant (k°f,h) of the reactant species were calculated. Cyclic voltammetric study of zinc complex showed one electron diffusion controlled, quasi-reversible peaks at 50-250 mV/s sweep rates. Antimicrobial study of zinc complex showed that zinc complex found to be more potent than uncoordinated Schiff base.