The Artificial Intelligence (AI) can promote research and find optimal solutions for complex and unstable situations. COVID-19 highlights the urgent need to innovate and offer modern solutions. Those solutions must meet the business requirement but also the current circumstances. In this paper, we are going to describe a new E-service application: Online Donation to Help Fight COVID-19. Our online donation software is perfect for nonprofits. The application has many features to suit our needs and their support response time. We use the Machine learning technique K-Nearest Neighbor to identify the ideal beneficiaries (school, hospital…). Our project can resolve the problem of donation management and establish the transparency and trust.