Over the last three decades, transportation has become one of the main energy-consuming sectors around the world and, as a result, large amounts of emissions are produced, contributing to global warming, climate change, and health problems. Therefore, huge investments and efforts have been made by governments and international institutions to find new renewable and clean sources of energy. As a contribution to these efforts, this study determined the practical energy and environmental implications of replacing conventional speed humps with energy-harvesting speed humps in Nablus city, Palestine. The study was implemented using an energy-harvesting speed hump (EHSH) system developed in the laboratories at An-Najah National University and based on comprehensive traffic volume counts at all speed humps’ locations. In addition, a traffic volume prediction model was developed in order to determine the implications over the next 10 years. As a result of the study, the expected annual amount of generated energy was determined. Moreover, the expected reduction in greenhouse gas (GHG) emissions and the reduction in the cost of roadway network lighting were determined based on the current and future traffic conditions.