Background One of the occupations that suffer from musculoskeletal disorders (MSD) is the teaching profession. Although teachers are known to have a variety of health and safety issues, few studies have actually been published that relate to somatic health problems of teachers, especially studies conducted in Malaysia. From this viewpoint, it is clearly important to investigate psychosocial factors, and MSD with depression as mediator among school teachers. Methods The study aimed to determine the incidence of MSD for school teachers in 15 primary schools in Kuala Lumpur during a 6-month period. Secondly, the study also sought to examine the relationships between psychosocial factors, depression and MSD among teachers. Thirdly, the study aimed to explore depression as mediator. The hypothesis addressed by this cross-sectional study was that depression would prove to be a mediator for the psychosocial factors affecting MSD. Results The incidence of MSD during the previous 6 months was 80.1% (95% CI: 75.8–84.2%), with 80.5% of female and 77.5% of male teachers reporting symptomatic pain during that period. There were significant relationships between psychosocial factors, depression, and MSD. The results indicated that in relation to psychosocial factors, depression ( r = − 0.25, p < .01) and musculoskeletal disorder ( r = −.17, p < .01) were both negative. In addition, depression was positively related to musculoskeletal disorder ( r = .30, p < .01). Furthermore, depression appeared to have a partially mediating effect on the relationship between psychosocial factors and MSD. Conclusions The findings in this study demonstrate that psychosocial factors and depression are significant predictors of MSD among teachers. Recognizing the relationship between these variables will help in arranging, planning or actualizing preventive intervention programs for teachers with the hope of lessening the incidence of MSD. This study also provides awareness for teachers and the Malaysian Ministry of Education regarding the issues of MSD in the workplace.

Working through pain is influenced by work, social culture and religious beliefs. Workplace MSDs interventions that focus on the impact of physical and psychosocial hazards with emphasis on addressing adverse workstyles should take into account aspects related to work and social culture of the target population. Changes are recommended at both employee and management levels such as better communications and understanding concerning workplace problems with regards to minimizing MSDs at work.

Prevalence and predictors associated with musculoskeletal disorders (MSDs) vary considerably between countries. It is plausible that socio-cultural contexts may contribute to these differences. We conducted a cross-sectional survey with 1184Malaysian and Australian office workers with the aim to examine predictors associated with MSD discomfort. The 6-month period prevalence of self-reported MSD discomfort for Malaysian office workers was 92.8% and 71.2% among Australian workers. In