The aim of this paper is to advance the position that Nigeria's indigenous technologies present significant opportunities for local economic transformation and, to some extent, for global competitiveness. An analysis of three major indigenous technology clusters in Nigeria, as well as a review of three successful country cases was performed. This was with a view to identifying structural and policy directions for the country. The study provided preliminary insight into a very broad landscape and call for further analyses relating to mapping the Indigenous Knowledge (IK) and Indigenous Technology (I-Tech) systems of economies.