Lycopene is a hydrocarbon phytochemical that is present in red vegetables and fruits, several studies reviewed the pharmacological properties of Lycopene across years ago and in different aspects including inflammation, cardiovascular disease, prostatic cancer and different dermatological complaints. Objective: we investigated the potential impact of two different doses of topical Lycopene and as add on therapy to Clobetasol on Psoriasis model that induced by Imiquimod in mice. Methods: This was accomplished by dividing 48 mice into six groups (8 mice per each group). All groups received Imiquimod for induction of Psoriasis (except Group I which is healthy group) across the experiment days. Group II (Induction group) received Petrolatum gel (Vaseline) for six days after 6 days induction period with Imiquimod. The rest groups III, IV,V,VI received Clobetasol propionate 0.05%, 0.125 mg/ml Lycopene, 0.25 mg/ml Lycopene and combination of 0.25 mg/ml Lycopene and 0.05% Clobetasol propionate ointments respectively once daily for six days after 6 days of induction period with Imiquimod.

Background: The incidence of thyroid cancer has increased during the last three decades. Many studies have been conducted to determine whether there is a link between viral infections and thyroid carcinogenesis. Human Papilloma viruses (HPV) are related to a variety of benign and malignant tumors. P57 is a member of the Cip/Kip family that binds and inhibits all cyclin/CDK complexes, resulting in cell-cycle arrest as well as cell growth. Objective: This retrospective study designed to investigate histopathological expression of thyroid cancer tissues in relation to the concordant HPV31/33 infection and p57 protein over-expressions. Patients and Methods: HPV31/33 DNA and P57-gene protein expression were evaluated in 116 thyroid tissues. The samples related to 36 patients with thyroid carcinoma, 40 thyroid adenoma, and 40 normal thyroid tissues. In situ hybridization (ISH) used to identify HPV31/33-DNA, whereas immunohistochemistry (IHC) used to assess P57-gene expression. Results: Regarding thyroid carcinoma group, HPV31/33DNA-ISH are responses observed in 77.8%, in 30 % of thyroid adenomas group, and in 22.5 %of normal thyroid tissues group. The difference between HPV31/33 in thyroid malignancies and the control group was statistically significant. The p57 protein detected in 75% thyroid cancer tissues and in 52.5 % adenoma thyroid tissues, whereas 35% of the investigated normal thyroid tissues showed IHC-reactions. The difference in the detected percentages of P57 protein was statistically significant in thyroid tissues between the study groupsin relations to the control group. Conclusions: The significant detection of HPV31/33 along with over-expressed P57-gene in thyroid cancer patients could support a possible role for both HPV 31/33 along with this p57 protein in thyroid pathogenesis and for carcinogenesis.

Objectives: This study was carried out to explore the possible anti-inflammatory effect of ibudilast on acetic acid-induced colitis in rats. Methods: Fifty adult Wistar rats were separated into 5 groups, including the control group, acetic acid group, acetic acid + vehicle, acetic acid + sulfasalazine (100 mg/kg/day)group, and acetic acid + ibudilast (30 mg/kg/day) group. Colitis was induced in rats by the inter-rectal installation of 2 ml of 4% (v/v) acetic acid. Sulfasalazine and ibudilast were administered orally for ten days after 2 hours of induction. Results: The treatment with ibudilast significantly reduced disease activity index (DAI), macroscopic colonic scores (MAC), and histopathological changes induced by acetic acid. Also, ibudilast markedly decreased the expression of proinflammatory markers (TNF-α and IL-1β) in colonic tissue. Moreover, ibudilast inhibited myeloperoxidase (MPO) enzyme activity that was increased by acetic acid. Conclusion: Therefore, ibudilast may have a therapeutic effect in the management of ulcerative colitis.

Breast cancer is the leading cause of death in women and ranks second in cancer-related mortality in worldwide. NF-𝜅B2(P52) is one of the mammalian NF-κB transcription factor family that expressed in breast tumors. BCL2 is an anti-apoptotic protein that also acts as a medical prognostic biomarker for breast carcinoma. This research was aimed to find out the IHC expression of P52 and BCL2 in 67 histological specimens of breast cancer patients and evaluate their correlation with clinicopathological features. Protein IHC expression of BCL2 and P52 was observed in 45 and 46 respectively. There was no correlation between P52 and BCL2 expression with any clinicopathological parameters, while a strong correlation between protein expression of P52 and BCL2.