Background: The increase in prescriptions of antiretrovirals (ARVs) implies the increasing occurrence of side effects, including skin manifestations. The objective of this work was to identify the epidemiological and therapeutic aspects of drug eruptions during ARV treatment in the support and counseling units (SCU) of commune IV of the district of Bamako. Material and methods: In a documentary study, the data of patients living with HIV (PLHIV) followed in the SCUs between January 2008 and December 2010, i.e. 3 years, in strict respect of their confidentiality were collected. Parameters of interest included epidemiological, clinical and therapeutic characteristics. Results: The frequency of drug eruptions was 2.85% of cases, ie 50 patients out of 1748 PLWHA. Women accounted for 76% of cases with a sex ratio of 0.32. The mean age was 30.8 ± 11.46 years with extremes ranging from 5 to 60 years. PLHIV were in WHO clinical stage III, or 48% of cases. The mean time to onset of drug eruption was 23.5 ± 17.7 days. Common clinical manifestations were pruritus (24%), rash (22%) and Lyell’s syndrome (12%). 96% of patients (48 cases) were on ARVs, of which 78% were on nevirapine and 14% on efavirenz. The treatment was symptomatic. Conclusion: Antiretrovirals are sources of drug eruption despite their benefits in the treatment of HIV/AIDS. Rigorous monitoring is essential to prevent these harmful effects.

Background: Fahr syndrome associates a set of neuropsychiatric manifestations with bilateral calcifications in the basal ganglia and phosphocalcic disorders. Neuromeningeal cryptococcosis can be present in its manifestations, neuropsychic disorders with or without meningeal signs. The objective was to describe a rare association between Fahr syndrome and neuromeningeal cryptococcosis which can be expressed by the same clinical symptomatology in the context of co-infection with the human immunodeficiency virus (HIV) and the hepatitis B virus (HBV). Presentation: A 37-year-old patient without pathological history, who presented behavioral disorders that led to a fight with those around her and a psychiatric consultation. Then, she was hospitalized in the infectious diseases Department upon discovery of her HIV status and viral hepatitis B. She was logorrheic with behavioral disturbances and subsequently presented with tonic-clonic convulsions. Laboratory tests and imaging have concomitantly discovered Fahr syndrome due to pseudohypoparathyroidism and neuromeningeal cryptococcosis. The correct management of these two pathologies enabled stabilization of the patient's clinical condition with regular monitoring for HIV-HBV coinfection. Conclusion: Farh syndrome and neuromeningeal cryptococcosis are two different entities but sometimes similar symptoms and risk factors. Treatment of metabolic disorders combined with anticryptococcal therapy improved the prognosis.