Background: SNEDDS was chosen because of the ability to increase the absorption of drugs with low water solubility such as active substances derived from plant extraction. Objectives: This study aimed to create an innovative dosage by utilizing new drug delivery systems in the form of SNEDDS (Self Nano-emulsifying Drug Delivery System) using the active substances of papaya leaf extract (Carica Papaya L.) that is efficacious as an anti-inflammatory. Methods: SNEDDS of Papaya (Carica papaya extract L.) was prepared through the high-energy method. Dried papaya leaves were macerated using 96% ethanol, and the extract was then evaporated using a rotary evaporator to obtain viscous extract. Four formulations of SNEDDS were produced with isopropyl myristate as the oil phase, PEG 400 as the surfactant, and tween 80 as the co-surfactant. The evaluation included particle size, % transmittance, and freeze-thaw cycles. In vivo SNEDDS antiinflammatory activity was tested in balb-c mice induced with 1% acetic acid and then compared with mefenamic acid (NSAIDs). Results: The test results showed that all of the formulations had a particle size of <200nm and >90% transmittance. The SNEDDS anti-inflammatory activity test in vivo indicated that the percent inhibition of pain in SNEDDS of papaya leaf extract reached 94.55%. Conclusion:The SNEDDS formula of papaya leaf extract marked by F4 could fulfill the criteria of good stability parameters with the smallest particle size of 77.1 nm. The percent of pain inhibition of SNEDDS papaya leaf extract in balb-c mice induced by acetic acid was 94.55%.

Uv-Vis spectrophotometry is an analytical method that can be used to determine the levels of domperidon maleate contained in transdermal patches with different polymers. The analysis method needs to be validated to prove that it can provide measurement results that match its designation. The purpose of this study is to prove that uv-vis spectrophotometry methods can provide the specificity, linearity, thoroughness, and precision that meet the requirements. In this study, linearity was known by calculating the r value on the curve of the relationship between levels and absorbance. Precision is obtained based on rsd value. Accuracy is calculated based on the return value. Selectiveity is known by means of identity confirmation that calculates the absorbance ratio at different wavelengths. The results showed that the method meets the requirements with a value of r=0.999; RSD precision results at a level of 10 ppm obtained RSD 0.236%. The accuracy values of 80%, 100%, and 120% in the matrix of transdermal domperidon maleate patches with PVA and PVP polymers respectively recovery was 99.50%, 101.15%, and 99.13%.. In the matrix of transdermal patches domperidon maleate with polymers HPMC and Na-CMC respectively recovery was 100.91%, 100.31%, and 100.67%. In the matrix of transdermal domperidon patches with HPMC and EC polymers respectively recovery was 98.00%, 98.00%, and 99.00%. The identity confirmation results on the transdermal domperidon patch matrix with PVA and PVP polymers, HPMC and Na-CMC, as well as HPMC and EC respectively have ratio value close to the standard solution with an average value of 0.800; 0,806; and 0.808. It can be concluded that the method of analyzing the levels of domperidone maleate in matrix of transdermal patches has qualified for good validity.