Nurses' spirituality is believed to affect their performance. However, how to describe the spirituality of nurses and their performance in general hospitals and Islamicbased hospitals requires further research. The study aimed to compare the spiritual and performance of nurses between general hospitals and Islamic based Hospital. This was a quantitative research with descriptive comparative design. This research was conducted at Puri Cinere General Hospital Jakarta with 104 respondents and Hajj Hospital Jakarta as Islamic based hospital with 112 respondents. Simple random sampling technique was used. The results showed significant differences in the spirituality of nurses between Islamic based hospitals and general hospitals with p value of 0.005. There was no significant difference in nurse performance between hospitals based on Islam and public hospitals with p value of 0.678. Recommendation for nurses to improve their knowledge about spirituality so that the quality of performance nurses will be increased as well.

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