Гастроэзофагеальная рефлюксная болезнь относится к числу наиболее частых нозологических форм в гастроэнтерологии. Лекция освещает во-просы патогенеза заболевания, рассматривает диагностические и лечебные подходы, дает алгоритмы ведения пациентов и дифференцированного применения лекарственных средств. Ключевые слова: гастроэзофагеальная рефлюксная болезнь, рефлюкс-эзофагит, пищевод Барретта, ингибиторы протонной помпы, альгинат, про-кинетики. Для цитирования: Вовк Е.И., Седякина Ю.В., Шамуилова М.М. и др. Гастроэзофагеальная рефлюксная болезнь в практике терапевта поликлиники: terra incognita. Consilium Medicum. 2020; 22 (8): 9–26. DOI: 10.26442/20751753.2020.8.200317

Over the last 10 years, the incidence of chronic pancreatitis (CP) has increased 4 times and nowadays is about 27.450 cases per 100 000 adults. In the outpatient gastroenterologist practice, patients with CP account for about 3545%, in the hospital gastroenterology department up to 2045%. CP criteria according to imaging methods fibrosis, duct dilatation and deformation, calcifications in the pancreatic parenchyma or its atrophy are formed at a late stage of the disease. Simultaneously, diagnosis at the early stage with potentially reversible changes remains difficult, due to the lack of clear instrumental and laboratory findings confirming minimal changes in the pancreas. However, some methods in combination with a detailed history taking, risk factors identification in comparison with the clinical features are of interest for the early diagnosis of chronic pancreatitis.

Gastroesophageal reflux disease (GERD) remains a major problem in gastroenterology. GERD phenotypes have recently been identified, but a key mechanism of pathogenesis is the effect of acidic stomach contents on the esophageal mucosa due to reflux. The role of alginates in GERD is expanding in terms of diagnosis, improvement of treatment outcomes, and prevention of relapse.