Background Aloe vera and Aloe ferox have over the years been among the most sought-after Aloe species in the treatment of ailments worldwide. This review provides categorized literature on the phytochemical and scientifically proven toxicological profiles of A. vera and A. ferox to facilitate their exploitation in therapy. Main body of the abstract Original full-text research articles were searched in PubMed, ScienceDirect, Research gate, Google Scholar, and Wiley Online Library using specific phrases. Phenolic acids, flavonoids, tannins, and anthraquinones were the main phytochemical classes present in all the two Aloe species. Most of the phytochemical investigations and toxicity studies have been done on the leaves. Aloe vera and Aloe ferox contain unique phytoconstituents including anthraquinones, flavonoids, tannins, sterols, alkaloids, and volatile oils. Aloe vera hydroalcoholic leaf extract showed a toxic effect on Kabir chicks at the highest doses. The methanolic, aqueous, and supercritical carbon dioxide extracts of A. vera leaf gel were associated with no toxic effects. The aqueous leaf extract of A. ferox is well tolerated for short-term management of ailments but long-term administration may be associated with organ toxicity. Long-term administration of the preparations from A. vera leaves and roots was associated with toxic effects. Short conclusion This review provides beneficial information about the phytochemistry and toxicity of A. vera and A. ferox and their potential in the treatment of COVID-19 which up to date has no definite cure. Clinical trials need to be carried out to clearly understand the toxic effects of these species.

It is degraded to free triglycerides and fatty acids by the secreted phosphatases of the plant family (sPLA2s). Plants have very few sPLA2s. Plant sPLA2s' molecular, biochemical, and catalytic properties are being studied. Three-dimensional structures are also included when comparing the two groups. Glycine max is used as a benchmark for comparing various organisms, including any herbal plants and small animals. In addition, they can be used as a type of signalling molecular. The functions of SPLa2 enzymes are well understood, however their ligand activities remain a mystery. Since the last review, sPLA2-binding proteins have evolved dramatically. Promiscuous SPLa2 proteins exist in nature for evolutionary reasons that we describe. As sPLA2s have a wide range of roles in the human body, they appear to be suitable therapeutic targets. New diagnostic and therapeutic techniques can be developed by using sPLA2s to interact with other proteins.

Many people suffer from ulcer, a disorder of the digestive tract. Simply put, it's an inflamed break in the skin or the mucus membrane lining the digestive tract. Whenever there is a change in the equilibrium, such as increased aggression or decreased mucosal resistance, ulceration develops. Reasons for this could include drug use, poor diet, stress, and other similar factors. Peptic ulcers are a general term for any type of stomach or duodenal ulcer. To develop, peptic ulcers need mucosal defences to be compromised in addition to gastric juice acid and peptic activity. Ulcers can be treated with a variety of synthetic medications. However, compared to herbal remedies, these drugs are more costly and more likely to cause side effects. According to the research, many different ayurvedic doctors and traditional medicine practitioners use different medicinal plants and polyherbal formulations to treat ulcers. Peptic ulcer disease treatment should focus on symptom alleviation, ulcer healing, and preventing recurrence. In this article, we'll take a look at some medicinal plants that have been studied for their potential use in peptic ulcer treatment and prevention, both in ayurveda and Western medicine.

COVID-19 outcomes may be more severe in lung cancer patients. As a COVID-19 pandemic spreads, it's critical to identify which people and malignancies are most susceptible. COVID-19 appears to have the worst results in lung cancer patients. Lung damage or reduced lung capacity can be caused by the disease itself or by cancer treatments such as radiation and surgery. The earlier lung cancer is diagnosed, the better the prognosis. As a result, early detection technology for cancer is in high demand. Early diagnosis in large population screens is closely connected to non-invasiveness and cost-effectiveness. As a result, microelectronic-based sensor technology may be used to construct sensitive biomarker detection systems. Various biosensors have recently recognized cancer-related proteins. Researchers are increasingly interested in testing for volatile metabolites found in the breath. Companion testing for innovative anti-cancer drugs and re-biopsy for new therapeutic uses are helping to speed up the development of lung cancer diagnostic tests. This review covers all current lung cancer diagnostic modalities in depth.

The function of obesity in an insulin-resistant syndrome associated with hyper insulinemia, hypertension, hyperlipidemia, atherosclerotic diseased illness is vital. Hunger, body weight and lipid profile investigations thus assess Calotropis procera extract in animal models. Adult Wister rats (180-240g) 8 were used in each experimental group. The impact of Cactus Kalahari on hunger, body weight and profile of lipids. (A) Control in weight, (B) obesity and CP+ obesity. Control obesity caused by material of cafeteria cuisine (CD). (CP was induced at (100 mg/kg/day po. for 50 days). Every 10 days, the food give, animal body weight, blood glucose, serum lipids level examined—serum and term tests for Liver Function and Renal Function Tests were checked. Our research has demonstrated that following obesity induction CP pretreatment and administration at 100mg/kg/day p<0.05) have resulted in substantial reductions in food consumption, increased body weight and improved lipid profile, liver enzyme and kidney function tests. Cafeteria food rats also showed considerable growth in body weight gain, famine, lipid profile, hepatic enzymes, and kidney function tests. When administered with a protein-rich food at the same time, the Kalahari extract prevented and reduced body weight gain and profile of lipid alterations in experimental induced obesity(fats) in rats.