Conventional cyclometalation of calix[4]arene bis(aryltriazoles) with iridium(III) chloride hydrate leads to unique meso architectures in which the Ir2Cl2 core is cross-bound by two (C^N)2-ligands, that allows further replacement of the...

Triazolated calix[4]semitubes comprising several binding sites were studied at complexation of Ag+ to get insight into the ability of the multitopic semi-tubular environment to host cation(s) in a structure-specific/switchable manner....

Semi-tubular bis(calixarenes) of photo-variable length were shown to be readily available by linking together two calix[4]arene macrorings by means of two bifunctional azobenzene or stilbene units. These biscalixarene cores were...

Synthetic water-soluble polymers are increasingly used for gene delivery, stabilization, and delivery of proteins, and as prospective antimicrobial and antiviral agents. Therefore, study of their interaction with lipid membranes is of special importance. Herein, we studied interaction of aliphatic cationic ionenes (recently tested for gene delivery efficiency) differed in the length of spacer between charged groups (and therefore in charge density) with anionic lipid membrane. A range of approaches such as measurement of particle size and electrophoretic mobility, liposome integrity, ATR-FTIR spectroscopy, isothermal titration calorimetry as well as atomistic molecular modeling was used. Ionene with a spacer of 10 methylene groups has been shown to be incorporated into membrane and interact with its inner hydrophobic part in contrast to ionenes with shorter spacer, which interacted only with outer polar head groups of lipids staying at the water−membrane interface. It affects membrane integrity and results in a different behavior of the polymer−liposome complexes. These findings are relevant for potential biomedical application of ionenes, including creation of composite polymer−liposome systems for drug delivery.

Acylation of magnesium enolates of acetophenones with the calixarene-based 1-acylbenzotriazoles was systematically studied to access scarcely available cone and 1,3-alternate calix[4]arenes having the synthetically/receptor valuable 1,3-diketone groups linked to the...