Background: Chemokine receptor CCR7 promotes survival in mature dendritic cells (mDCs). Results: Activated AMP-dependent kinase (AMPK) induces apoptosis in mDCs; CCR7 uses the kinases MEK1/2-ERK1/2 to regulate phosphorylation of AMPK on Ser-485 and consequently its inhibition. Conclusion: CCR7 uses a novel MEK1/2-ERK1/2-AMPK signaling axis to induce survival in mDCs. Significance: AMPK is a potential target to regulate mDC-mediated immune responses.
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