No abstract

No abstract

Glycosylated Vinyl Ethers by the Julia-Lythgoe-Kocienski Olefination: Application to the Synthesis of 2',5'-Dideoxydisaccharides and Carbohydrated β-Lactams. -A variety of α-carbohydrated pyridinyl sulfones react with aromatic and heteroaromatic aldehydes in a one-pot two-step procedure to afford glycosidic enol ethers with high (E)-selectivity. Only the reaction of (IX) with tBuCHO leads exclusively to a (Z)-product. Diels-Alder [4 + 2]-cycloaddition of (V) with aldehyde (VI) proceeds with complete regio-and endo-selectivity. [2 + 2]-Cycloaddition with chlorosulfonyl isocyanate leads to a single diastereomer of the β-lactam (XII). -(SANCHEZ, I. P.; TUROS*, E.;

Synthesis and Anticalcium Activity of New Compounds Containing the 2,3-Dihydro-1,4-dioxino[2,3-b]pyridine System.-The synthesis of the title compounds (III) starts with the known reaction of 2chloro-3-hydroxypyridine and epichlorohydrin. Both compounds show moderate anticalcium activity.-(SANCHEZ, I.; PUJOL, M. D.; GUILLAUMET, G.; MASSINGHAM, R.; MONTEIL, A.; DURENG, G.; WINSLOW, E.; Sci.