Stroke in younger patients is unusual and requires detailed diagnostic work-up due to possible rare causes such as syphilis infection. 1 Neurosyphilis is a central nervous system infection caused by Treponema pallidum (TP) that could be a treatable cause of stroke in some circumstances. 2 We present a young immunocompetent patient with meningovascular neurosyphilis, vasculitis of large intracranial arteries, and subsequent ischemic brain strokes. | CASE REPORTA 29-year-old white man was hospitalized at the Department of Neurology due to sudden motor dysphasia and right arm weakness. The onset of symptoms was preceded by a headache that occurred the day before hospital admission. The patient had a mild form of coronavirus disease 2019 6 months prior to admission, and a year earlier was assessed by a dermatologist due to a non-specific generalized rash without the need for specific medication.

Objective: To present 29-year-old patient with neurosyphilitic changes characterized by multiple acute ischemic brain strokes along with significant narrowing of several large intracranial arteries. After treatment of patient with ceftriaxone for 14 days following benzathine benzylpenicillin weekly for additional three weeks, meningovascular changes regressed.

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