Uveitis is a form of intraocular inflammation that can occur as a result of infection, injury, vaccination, or as a systemic manifestation of autoimmune or inflammatory diseases including sarcoidosis. Sarcoidosis is an inflammatory disease that involves the formation of abnormal granulomas in multiple organ systems. The hallmark of sarcoidosis is a non-caseating granuloma seen on biopsy. Here, we present a case report of a healthy 56-year-old Caucasian female who presented with uveitis sarcoidosis that was presumably initiated after administration of the Shingrix vaccine. Shingrix is a new attenuated subunit vaccine for Varicella Zoster Virus with an AS01B adjuvant that can result in a potent immune response. The Shingrix vaccine is made using Chinese hamster ovary cells which can contaminate the final vaccination product. Together, through the process of molecular mimicry and strong induction of the immune response, administration of Shingrix may have caused or exasperated this patient’s autoimmune etiology.

Cerebral toxoplasmosis is the most common opportunistic central nervous system (CNS) infection, affecting patients with advanced/untreated acquired immunodeficiency syndrome (AIDS). Cerebral toxoplasmosis is caused by the parasite Toxoplasma gondii typically and it usually occurs in immunecompromised patients with a CD4 count below 100cell/microL [1,2]. Left untreated, symptomatic patients can progress to coma within days to weeks, significantly increasing rates of this population’s morbidity and mortality. Cerebral toxoplasmosis is rarely encountered before the diagnosis of HIV infection is established, which is why seemingly benign neurological complaints can be easily overlooked.