Introduction: Leptospirosis is an acute bacterial disease, that has global distribution and manifests itself in subclinical or asymptomatic way, having mild or severe conditions that can lead to the death of the patient.Objective: To identify, among the municipalities of the state of Acre, Brazil, those with the highest incidence of leptospirosis between 2010 and 2015, and in addition, to determine the prevalence of this disease between the sexes.Methods: Descriptive study, of documentary character, with epidemiological base and quantitative approach. It was made by available documents through the Department of Informatics of the Unified Health System of Brazil (DATASUS) and also by the Health Secretary of State of Acre (SESACRE). Variables were selected as sex, age and year of notification. Regarding the analysis, it is emphasized that it was quantitative and descriptive and the results were presented in tables built in Microsoft Word.