The number of people living with dementia and Alzheimer’s disease is growing rapidly, making dementia one of the biggest challenges for this century. Many studies have indicated that depression plays an important role in development of dementia, including Alzheimer’s disease; depression, especially, during the late life may either increase the risk of dementia or even being its prodromal stage. Despite a notably large number of carried observational studies and/or clinical trials, the association between the late life depression and dementia remains, due to the complexity of their relationship, still unclear. Moreover, during past two decades multiple other (non-)modifiable risk and possibly protective factors such as the hypertension, social engagement, obesity, level of education or physical (in)activity have been identified and their relationship with the risk for development of dementia and Alzheimer’s disease has been extensively studied. It has been proposed that to understand mechanisms of dementia and Alzheimer’s disease pathogeneses require their multifactorial nature represented by these multiple factors to be considered. In this review, we first summarize the recent literature findings on roles of the late life depression and the other known (non-)modifiable risk and possibly protective factors in development of dementia and Alzheimer’s disease. Then, we provide evidences supporting hypotheses that (i) depressive syndromes in late life may indicate the prodromal stage of dementia (Alzheimer’s disease) and, (ii) the interplay among the multiple (non-)modifiable risk and protective factors should be considered to gain a better understanding of dementia and Alzheimer’s disease pathogeneses. We also discuss the evidences of recently established interventions considered to prevent or delay the prodromes of dementia and provide the prospective future directions in prevention and treatment of dementia and Alzheimer’s disease using both the single-domain and multidomain interventions.

We present a theoretical analysis of the vibrating resonator in cantilever and bridge configurations operating as ultrasensitive mass sensors. An exact solution of the problem has been obtained. For the small mass ratio, the asymptotic solutions (which relate the frequency shift, mass ratio, and position of the attached particle) have been derived. It has been shown that the mass and position of the attached particle for the cantilever configuration can be unambiguously resolved by the use of three consecutive resonant frequencies. For the bridge configuration, the particle mass can be deduced by using only two measured resonant frequencies.

Rapid progress in material science and nanotechnology has led to the development of the shape memory alloys (SMA) and the shape memory polymers (SMP) based functional multilayered structures that, due to their capability to achieve the properties not feasible by most natural materials, have attracted a significant attention from the scientific community. These shape memory materials can sustain large deformations, which can be recovered once the appropriate value of an external stimulus is applied. Moreover, the SMAs and SMPs can be reprogrammed to meet several desired functional properties. As a result, SMAs and SMPs multilayered structures benefit from the unprecedented physical and material properties such as the shape memory effect, superelasticity, large displacement actuation, changeable mechanical properties, and the high energy density. They hold promises in the design of advanced functional micro- and nano-electro-mechanical systems (MEMS/NEMS). In this review, we discuss the recent understanding and progress in the fields of the SMAs and SMPs. Particular attention will be given to the existing challenges, critical issues, limitations, and achievements in the preparation and characterization of the SMPs and NiTi-based SMAs thin films, and their heterostructures for MEMS/NEMS applications including both experimental and computational approaches. Examples of the recent MEMS/NEMS devices utilizing the unique properties of SMAs and SMPs such as micropumps, microsensors or tunable metamaterial resonators are highlighted. In addition, we also introduce the prospective future research directions in the fields of SMAs and SMPs for the nanotechnology applications.