Type of dentition, number of teeth in primary and permanent dentition, and appearance of the teeth in both dentitions have been extensively described in the literature. There are 20 teeth in primary dentition and 32 in permanent dentition. Teeth typically exhibit normal appearance, although small variations may appear. Abnormal teeth can be detected via careful clinical or radiographical observation. Variations in appearance, structure, and eruption of teeth can be influenced by factors such as genetics, trauma, certain drugs, and periapical lesions. These factors can alter teeth shape, number, size, and position. Teeth with anomalies can have a negative impact on a person’s appearance as well as functions such as eating and can even lead to psychological problems. They can be detected with different X-ray techniques, but cone beam computed tomography (CBCT) is the most precise.

Background / Aim. Determining the value of Gissane?s angle (GA) plays a role in diagnosis and prognosis of heel fractures, determining treatment methods and assessing the outcome of surgical treatment. Normal values of the GA vary in relation to ethnicity, age and gender of the examined group, which indicates its anthropometric significance. The aim of this study was to determine the range of normal GA values in the population of Central Serbia. Methods. GA was determined on lateral radiography of the foot of 145 subjects, both sexes (67 women and 78 men), with subjects divided into 6 age groups. The patients included in the study did not have a calcaneus fracture. The obtained results were processed in the Graph Pad program. Results: The average value of GA in Serbia was 110.8? ? 8.1, ranging from 93? to 132.9?. The mean value of GA decreased with age, and no difference was observed between women and men, except in the youngest age group were women had higher GA values than men. Conclusion. The results of the study showed a wide range of normal GA values, as well as the existence of a difference in subjects of different age and sex.

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common cause of elderly dementia. One of the main features of AD diseased brain are amyloid plaques, pathological depositions made of β-amyloid peptide, derived from β- amyloid precursor protein (APP). To assess how AD pathology affects synapses in the hippocampus, brain region to be one of the earliest with obvious pathological changes, we examined APPPS1 mice, transgeneticaly expressing human APP mutation (“Swedish mutation”) and human presenilin-1 mutation under the neuron-specific promoter, which develop AD symptoms early in life. We analyzed inhibitory and excitatory synapses using immunoflourescent staining and laser scanning confocal microscopy. In APPPS1 mice, inhibitory synaptic terminals labeled with vesicular inhibitory transmitter transporter (VGAT) were reduced in CA1 and CA3 regions of the hippocampus in APPPS1 mice compared to controls. This was true for both parvalbumin-positive and parvalbumin-negative terminals. On the other hand, excitatory synapses, coming from either hippocampal or entorhinal projections were similar between the genotypes. We conclude that first changes in the hippocampus caused by amyloid pathology affect inhibitory, but not excitatory synapses.