May–Thurner syndrome (MTS) is a relatively rare vascular condition that is characterized by external compression of the left common iliac vein by the right common iliac artery against the fifth lumbar vertebra. This condition slows the blood flow and is a predisposing factor for deep vein thrombosis (DVT). The key to its successful treatment is to remove the clot and fix the anatomical lesion. If this MTS diagnosis is missed, the recurrence of thrombosis will lead to significant morbidity and mortality. We report a case of 70-year-old female who had left leg DVT caused by MTS and was treated with catheter-directed thrombolysis along with long-term anticoagulation.

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