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The occurrence of a novel and specific inhibitor of Ca2+-dependent neutral protease in rat liver has been demonstrated. The partially purified product is a heat-stable and acid-stable protein of an approximate molecular weight of 3x10(5), and readily inactivated by tryptic digestion. The inhibition of Ca2+-dependent protease is not a result of the binding of Ca2+ by the inhibitor.

A case of neurinoma of the spinal accessory nerve without evidence of von Recklinghausen's disease is described. The difference in the clinical symptoms and radiological findings between this tumour and a jugular foramen neurinoma is especially emphasized. Other cases in the world literature are also reviewed and the peculiarities of the tumour are discussed.