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I956The extent of mercapturic acid formation in the chlorobenzene series appears to be greatest with monochlorobenzene, and only little, if any, is formed by the polychlorobenzenes (Jondorf et al. 1955). In contrast, very little mercapturic acid is formed by the monochloronitrobenzenes but considerable amounts are formed by many polychloronitrobenzenes. SUMMARY 1. The metabolism of o-, m-and p-chloronitrobenzene has been studied in the rabbit within the limits imposed by the toxicity of these compounds.2. The main products excreted in urine are phenols conjugated with glucuronic and sulphuric acids. Several aminoand nitro-chlorophenols have been identified by paper chromatography. 2-Amino-5-chlorophenol has been isolated from urine of rabbits dosed with p-chloronitrobenzene.3. From all three isomers about 10 % of the dose was excreted as free chloroaniline.4. Small amounts of nitrophenylmercapturic acid are formed from o-and p-chloronitrobenzene.We wish to thank Mrs B. G. Taylor for assistance with the quantitative analyses. Some preliminary experiments were performed by Dr Z. Hybs. We are indebted to the

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