Introduction: Critically ill children in the pediatric intensive care unit (PICU) are at high risk for developing nutritional deficiencies and undernutrition is known to be a risk factor for morbidity and mortality. Malnutrition represents a continuous spectrum ranging from marginal nutrient status to severe metabolic and functional alterations and this in turn, affects clinical outcome. Objectives: The aim of the study was to assess nutritional status of critically ill children admitted to the PICU and its association to clinical outcomes. Methods: Critically ill children age 6 months to 18 years were prospectively enrolled on PICU admission. Nutritional status was assessed by weight for age (WFA: underweight), weight for height (WFH: wasting), height for age (HFA: stunting) z-scores and mid upper arm circumference (MUAC: wasting) according to the WHO. (1,2) Malnutrition was defined as mild, moderate, and severe if z-scores were > −1, > − 2, and > −3, respectively. Hospital and PICU length of stay (LOS), duration of mechanical ventilation (MV), and risk of mortality (ROM) by the Pediatric Index of Mortality 2 (PIM2) were obtained. Sensitivity and specificity of the MUAC to identify children with wasting (WFH) were calculated. Results: Two hundred and fifty children (136 males), aged 81 months (23-167; median (25-75 th IQR)), were prospectively included in the study. The hospital LOS was 8 (4-16) days; PICU LOS: 2 (1-4) days; duration of MV, 0 (0-1.5) days;

reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. carbon dioxide 30 [27][28][29][30][31][32][33][34][35] mmHg and median temperature 37.1 [36.8-37.3]°C. After removal of artefacts, the mean monitoring time was 22 h08 (8 h54). All patients had impaired cerebral autoregulation during their monitoring time. The mean IAR index was 17 (9.5) %. During H 0 H 6 and H 18 H 24 , the majority of our patients; respectively 53 and 71 % had an IAR index > 10 %. Conclusion According to our data, patients with septic shock had impaired cerebral autoregulation within the first 24 hours of their admission in the ICU. In our patients, we described a variability of distribution of impaired autoregulation according to time. ReferencesSchramm P, Klein KU, Falkenberg L, et al. Impaired cerebrovascular autoregulation in patients with severe sepsis and sepsis-associated delirium. Crit Care 2012; 16: R181. Aries MJH, Czosnyka M, Budohoski KP, et al. Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury. Crit. Care Med. 2012.

Objectives Literature assessing the optimal means of providing academic advisement in pharmacy education is limited. The objective of this study was to describe students’ perception of advising within a school of pharmacy. Methods A 27-question survey was developed utilizing Qualtrics and sent to all students at one school of pharmacy. Baseline descriptive data regarding frequency and format of meeting with the assigned advisor were collected, as well as students’ opinions of these meetings. Key findings Of 282 students who were sent the survey, 90 responded (31.9%). The majority of students preferred to meet with their faculty advisor in a group as compared with one-on-one (59 versus 29, 67%). Most students found the advisor/advisee relationship beneficial (n = 77, 85%). Conclusions There was no statistically significant difference in student perception of the quality or value of advisor/advisee meetings between students who met in a group or one-on-one with their advisors.

Invasive meningococcal disease (IMD) is an uncommon but life-threatening disease. In France, the estimated incidence is 0.79/100000 inhabitants in 2015 but data relative on burden, sequelae and costs are scarce. This study aimed to describe hospitalized patients with confirmed IMD diagnosis, and to characterize their care pathway including for sequelae. Methods: A retrospective SNIIR-AM cohort (a French national healthcare claim system of nearly 66 million) analysis of all IMD patients-related hospitalizations between 01-Jan-2012 and 31-Dec-2017 was based on the health care consumption and followed up until either death or study end (31-Dec-2017). This cohort has been matched 3:1 with a control group (non-IMD hospitalized patients) according to age, sex and geographical area. The sequelae were identified during or after IMD hospitalizations (ICD10 code A 39, related/associated) through device or drugs use as surrogate. Results: A total of 3532 patients were hospitalized for IMD during the analyzed period (mean of 588 cases hospitalized/ year); average age was 29.7 years old (YO), among them 52% were males. Two hospitalization peaks: infants under one year of age (13.3%) and adolescents between 15 and 19 YO (11%). Average duration of hospitalization: 14.8 days (Standard Deviation-SD=24 days) for all cases; 10.0 days (SD=13.7 days) for subjects , 25 YO. A significantly higher proportion of IMD in Universal-Complementary-Health-Coverage affiliated patients was observed compared to controls in all age groups except those over 60 YO. A total of 456 (12.5%) patients died, 293 (8.3%) deaths occurred during the initial hospitalization. Sequelae have been identified in 1139 (32%) of survivors, one sequela for 21.7% and at least two for 10.5%. The most common being renal impairment (11.3%), epilepsy (8.7%) and depression/anxiety (8.0%). Conclusions: These data confirm the morbi-mortality of IMD, especially in infants and emphasize the importance of their primary prevention to avoid complications /sequelae and deaths.