In this retrospective study all 86 corneal transplantations performed for keratoconus in the Rotterdam Eye Hospital between 1969 and 1978 were included. Sixty seven perforating and 19 lamellar corneal grafts had been performed. The average follow-up was 59 months. Immune reactions occurred 12 times in 11 eyes with a perforating corneal graft (16%); in no case did this lead to permanent opacities in the graft. The visual result of the perforating graft is in general better than that of the lamellar graft. A lamellar graft is indicated, in our opinion, when the risk of trauma is high and the opportunities for follow-up insufficient, and when the peripheral cornea is markedly thin. In most cases we prefer a perforating graft because the results are better.
Indomethacin 0.5% solution eyedrops inhibit the prostaglandin effects after extracapsular cataract extraction combined with intraocular lens implantation. In a double-blind study Indomethacin was compared to Dexamethason and placebo using corneal thickness and iris vessel dilatation and leakage as parameters for postoperative irritation. The present evidence indicates that Indomethacin is an important additive medication to diminish the postoperative reaction.
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