Rapid industrialization and growing population result to high demand for energy. Depletion and rise in price of petroleum as well as environmental pollution necessitates the need for alternative source of fuel, hence bioethanol production. Rice bran (Oryza sativa), Corn bran (Zea mays) and Sorghum bran (Sorghum guinense) and saw dusts of Khaya senegalensis (Red wood), Terminalia superba (Black wood), Gmelina arborea (White wood), were used for the study. The yeasts used for the study were isolated from fermented beverages (Sorghum beer, Millet beverage and Palm wine). The results of the lignocellulosic biomass of white saw dust, red saw dust, black saw dust, rice bran, corn bran and sorghum bran revealed cellulose components as 77.78%, 75.55%, 68.59%, 64.83%, 54.82% and 55.14% respectively. A total of 25 yeasts were isolates and identified using API 20C AUX strip. The yeast isolates, K2, B5, B7 and P1 had the highest ethanol tolerance value of 14%. The results showed that the ethanol-producing ability of the yeast isolates ranged from 4.1% to 10.3%. Fourier Transform Infrared Spectrophotometer (FTIR) and Gas Chromatography and Mass Spectrometry (GC-MS) analyses showed that ethanol is the main compound produced by yeasts from the lignocellulosic materials. This study revealed that Saccharomyces cerevisiae isolated from palm wine (P1) is best in ethanol production and tolerance, and this high prolific strain can be exploited or engineered for ethanol production. Therefore, Lignocellulosic biomasses are recommended as raw materials for producing ethanol, which is a promising alternative energy source as against the depleting petroleum.

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Background Diabetes mellitus is one of the leading causes of morbidity and mortality globally. Although synthetic hypoglycemic agents are commonly used to manage this disorder, such medications, besides being unable to cure the disease, are expensive and associated with side effects. Conversely, medicinal plants have emerged as effective, safe and affordable alternative treatments. Boswellia dalzielii plant has been reported to possess ethnomedicinal properties for the treatment of various health conditions; however, scientific studies exploring this plant as antihyperglycemic agent are still limited. Thus, this study evaluated the antihyperglycemic activity of aqueous stem bark extract (ASBE) of B. dalzielii in alloxan-induced diabetic Wistar albino rats. Methods Phytochemical screening of the ASBE of B. dalzielii was conducted. Twenty male Wistar albino rats weighing 100–150 g divided into 4 groups (A–D) of five rats were used for the study. Group A served as the normal control and received neither ASBE of B. dalzielii nor glibenclamide. The treatment for the other three groups was as follows: Group B, 10 mg/kg of glibenclamide (diabetic control); Group C, 500 mg/kg ASBE of B. dalzielii; and Group D, 1000 mg/kg ASBE of B. dalzielii. Treatments were administered orally every 24 h for a period of 2 weeks. Blood glucose level and body weight were evaluated at weeks 0, 1 and 2. Histomorphological features of the rats’ pancreas in all the groups were compared. Results The phytochemical analysis revealed the presence of alkaloids, saponins, tannins, cardiac glycosides, flavonoids, carbohydrates, steroids and triterpenes. The two different doses of the plant extract significantly reduced blood glucose level at weeks 1 and 2 (all p < 0.05), with the 1000 mg/kg dose demonstrating a greater reduction compared with glibenclamide at week 2 (p = 0.014). However, only the 500 mg/kg dose led to restoration, albeit slight, of the pancreatic islet cells. Conclusion This study suggests that B. dalzielii plant exhibits a potent antihyperglycemic activity evidenced by reduced blood glucose levels and slight restoration of pancreatic islet cells. This plant could be, therefore, considered in the treatment of diabetes mellitus. Graphical Abstract

Background Diabetes is a major public health problem with increasing prevalence globally. Plant-based medicines for diabetes are gaining popularity across the world due to perceptions of efficacy, safety and cost-effectiveness. The plant, Parinari macrophylla, has been widely reported to possess potent ethnomedicinal properties especially in the northern part of Nigeria. However, there has been no scientific documentation of this plant to be used as an antidiabetic agent. The objective of this study was to investigate the antidiabetic effect of aqueous stem bark extract of P. macrophylla in alloxan-induced diabetic Wistar rats. Phytochemical screening and acute toxicity studies were conducted. Wistar rats weighing between 100 and 150 g were used for the study and diabetes was induced using alloxan monohydrate (150 mg/kg) intraperitoneally. The animals were treated with different doses of aqueous stem bark extract of P. macrophylla (1000 mg/kg and 2000 mg/kg) for 2 weeks. Blood glucose levels and body weight were then monitored. Histopathological investigation of pancreatic tissue was also conducted. Results The phytochemical analysis revealed the presence of alkaloids, saponins, tannins, cardiac glycosides, carbohydrates, steroids, and triterpenes as secondary metabolites. The acute toxicity test revealed no mortality with a median lethal dose determined to be above 5000 mg/kg. Although the two different doses of aqueous stem bark extract of P. macrophylla decreased blood glucose levels at weeks 1 and 2, a statistically significant difference (P < 0.05) was only observed for the group treated with 2000 mg/kg dose compared to the diabetic control group at week 2. The histological investigation revealed that the two different doses of aqueous stem bark extract of P. macrophylla caused regeneration of pancreatic islet cells, with the 2000 mg/kg dose being more evident. Conclusion This study suggests that the stem bark extract of P. macrophylla possesses a potent antidiabetic effect and may potentially be used to treat diabetes and associated complications. Graphical Abstract

Medicinal utilization and phytochemical composition of Baobab tree (Adansonia digitata L.) in Zaria Local Government Area of Kaduna State was studied. Twenty (20) questionnaires were randomly administered in each of the six (6) districts to make a total of one hundred and twenty questionnaires (120). Ninety (90) were retrieved. The result revealed that the plant parts (leaves; stem; bark and seed) can be used in treatment and prevention of various diseases such as tuberculosis; anemia; malaria; dysentery; diarrhea; joint pains; serves as anti-diabetic; fever; urinary infection e t c. Infusion is the major (43.33%) method of herbal preparation. Parts of the plants species used in preparing the herbs include: the leaves; bark; root; seeds and fruits. Majority of the herbal are consumed in a dried form. Demographic characteristic of the respondents were also examined. The percentage of Male was (43.34%) while that of their female counter part was (56.66%). Majority (43.33%) of the respondents were between 31 – 40 years age bracket and majority (44.44%) are married with majority (37.78%) having 1-5 house hold size. 45.56% of the respondents had secondary education while 2.22% had no formal education and majority (51.11%) are traditional healers. Quantitative phytochemical analysis revealed the presence of tannins; alkaloids flavonoids; terpenoids; saponins and phenolic acid in various concentrations as there were significant differences (p < 0.05) between these phytochemicals and their plants parts. The presence of varied active ingredients in the different parts of these plants explains their diverse use in the treatment of different disease conditions. However, it is recommended that due to the increased interest in baobab products (especially on its medical utilization) and slow growth of the plant research should be directed on how to develop a new cultivar with short maturation period. Also, the local population particularly the youth should be educated and also encouraged to learn more about the tradition medicine knowledge in order to preserve it from being lost with the old genera.