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I N 1932, Ahumada and del Castillo (1) published the history of a patient presenting galactorrhea and amenorrhea with symptoms of estrogenic insufficiency and absence of urinary gonadotropins. To this observation, the first to our knowledge, other studies made during the last years in the Endocrinology Service of the Rivadavia Hospital have been added. In these new cases the existence was verified of galactorrhea with amenorrhea and urinary gonadotropin (FSH) decreased below 6 mouse units in twenty-four hours.At this stage of our observations we were informed that at the meeting of the Association for the Study of Internal Secretions held in Atlantic City in June 1951, a communication was presented by Forbes, Henneman, Griswold and Albright under the title "A syndrome, distinct from acromegaly, characterized by spontaneous lactation, amenorrhea, and low follicle-stimulating hormone excretion." Of this paper, we know only the abstract published in the July 1951 issue of The Journal of Clinical Endocrinology (2).We shall refer to only 4 such cases that we have had the opportunity to observe. We consider that the symptomatology presented by them coincides with that which characterizes the patients referred to by Ahumada and del Castillo (1932) and by Forbes et al. (1951). REPORT OF CASES Case 1A r . P., an 18-year-old, single girl, was seen by us complaining of secondary amenorrhea and a milky secretion from the mammary glands. These disturbances began one year before observation. She complained of headache and her weight had increased 4 Kg. since the onset of her disease. During the year of evolution of her amenorrhea she had two menstrual periods, under estrogen therapy.

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