Sample mediastinal lymphadenectomy may not be appropriate in surgery for non-small cell lung cancer because skip metastases were found in 25% of patients without N1 nodal involvement.

Conclusions: This meta-analysis shows a modest but significant improvement in overall survival and local failures at the expense of a clearly increased severe esophagitis. Difficulties of increased treatment frequency and the continuous therapy over weekends make these strategies hard to adopt. On the other hand, due to the heterogeneity of altered fractionation modalities among the trials included, our results should be considered with caution and must be interpreted as an hypothesis generator. TRIAL n HFRT type Chemotherapy Median OS p Ball 204 60 Gy in 3 wks Weekly CBDCA 14.7 vs 15.4 ns Saunders (CHART)

No abstract

No abstract

The extend of lymph node involvement in patients NSCLC is the cornerstone of staging and influences both multimodality treatment and final outcome. We studied safety, accuracy and characteristics of intraoperative ultrasound guided systematic mediastinal nodal dissection in patients with resected NSCLC.