The findings of the present trial indicate that 5 mg nebivolol once daily is an effective antihypertensive agent. It can therefore be recommended as a useful alternative first-line treatment option for the management of patients with mild to moderate essential hypertension.

A simple nucleic acid amplification test (NAAT) was developed for detection of Ureaplasma urealyticum infection based on the PCR amplification of the urease gene (UU1/UU2 Test). DNA was extracted from urogenital swabs and a 225-bp long DNA fragment was amplified by PCR. NAAT was compared to the commercial amplification kit for sexually transmitted disease reference assay. The sensitivity and specificity of the UU1/UU2 Test were determined to be 100 and 98.9%, respectively. The overall prevalence rate in this group of patients was found to be about 236 per 1000 (283 and 166 per 1000 in females and males, respectively). These data demonstrate that UU1/UU2 Test is suitable for effective epidemiological screening and/or diagnostic practice.

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20103 Background: EGFR is involved in the epidermal growth factor pathway that regulates cellular processes and is associated with the development of malignancy.EGFR targeted therapy could be an alternative option to improve clinical outcome in tumors with EGFR expression. Methods: From 09/2004 till 12/2005 we evaluated histologic specimens of 130 patients (89 male, 41 female) with colorectal cancer. EGFR expression was examined by immunohistochemistry using theEGFR Detection Kit (Dako Corporation) in paraffin-embedded colon/rectum tumors and graded as percentage of cells stained. Results: EGFR positivity (1% and more) was observed in 106 pts (81.5%) and EGFR negativity in 24 pts (18.5%). Median of positivity in percentage is 40 (1–95). Conclusions: The EGF receptor is overexpressed in many human tumors and is a promising therapeutic target. No significant financial relationships to disclose.

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