Previous studies of contracting muscle with low loading and partial vascular occlusion demonstrated hypertrophy and strength adaptations similar to and exceeding those observed with traditional moderate to high resistance (Shinohara M, Kouzaki M, Yoshihisa T, and Fukunaga T. Eur J Physiol 77: 189-191, 1998; Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, and Ishii N. J Appl Physiol 88: 2097-2106, 2000; Takarada Y, Sato Y, and Ishii N. Eur J Physiol 86: 308-314, 2002). The purpose of the study was to determine the anabolic and catabolic hormone responses to light resistance exercise combined with partial vascular occlusion. Three experimental conditions of light resistance with partial occlusion (LRO), moderate resistance with no occlusion (MR), and partial occlusion without exercise (OO) were performed by eight healthy subjects [mean 21 yr (SD 1.8)]. Three sets of single-arm biceps curls and single-leg calf presses were completed to failure with 1-min interset rest periods. Workloads of 30 and 70% one repetition maximum for each exercise were lifted for the LRO and MR trials, respectively. Blood samples were taken preexercise, postexercise, and 15 min postexercise for each experimental condition. Lactate increased significantly in the LRO and MR trials and was not significantly different from each other at any time point. Growth hormone (GH) increased significantly by fourfold from pre- to postexercise in the LRO session but did not change significantly during this time period in the MR and OO trials (8.3 +/- 2.3 vs. 2.1 +/- 1.2 and 2.6 +/- 0.94 microg/l; respectively, P < 0.05). There were no changes in resting total testosterone [T; mean 15.7 +/- 1.6 (SE) nmol/l], free testosterone (FT; 54.1 +/- 4.5 pmol/l), or cortisol (267.6 +/- 22 nmol/l) across all trials and times. In conclusion, with similar lactate responses, light exercise combined with partial vascular occlusion elicits a greater GH response than moderate exercise without occlusion but does not affect T, FT, or cortisol.

The purpose of the study was to determine how manipulation of peripheral blood flow during resistance exercise using a light load affected perception and physiological measures compared with moderate load resistance exercise and a control trial. Seven subjects performed a 3 (session) by 2 (biceps curls and calf extensions) within-subjects study that was randomized and counterbalanced across 3 weeks. The 3 sessions included (a) light resistance exercise (3 sets to failure) at 30% of 1 repetition maximum (1RM) with partial occlusion (LRO), (b) moderate resistance at 70% of 1RM with no occlusion (MR), and (c) partial occlusion without exercise (OO). Ratings of perceived exertion (RPE), pain, and heart rate were assessed immediately after each set, whereas blood samples were taken before, immediately after, and 15 minutes after exercise. Results demonstrated that RPE and pain were lower in the OO condition than that in the MR and LRO conditions for biceps curls and calf extensions, Fs(2 ,24) = 22.75, 20.86, ps < 0.0001 and Fs(2,24) = 18.95, 24.52, ps < 0.01; however, no significant differences were noted between MR and LRO conditions. Heart rate was significantly higher for the LRO condition when compared with the MR trial, F(2,18) 20.12, p < 0.001. Results suggest that when partial vascular occlusion with a light load was applied, both pain and effort sense were altered to a similar degree as moderate loads but no occlusion. The practical application of results were that individuals may be better able to tolerate perceptual change at low loads with partial occlusion because joint stress may be minimized while local muscle metabolic demands increase, making resistance training maximally effective and minimally stressful on joints. Perceptual tracking of effort and pain may aid coaches who attempt this protocol.

We describe a 28-year-old subject employed as a roofer in a construction company since the age of 19, who developed work-related symptoms of a cough, shortness of breath, wheezing, rhinitis and headaches. A description of a usual day at work suggested that the symptoms worsened while he was sawing corrugated fiber cement. Baseline spirometry was normal, and there was a mild bronchial hyperresponsiveness to carbachol. A skin patch test to chromium was negative. A specific inhalation challenge showed a boderline fall in forced expiratory volume in 1 s (FEV1) after exposure to fiber cement dust. Exposure to nebulization of potassium dichromate (K₂Cr₂O₇), at 0.1 mg·ml^–1 for 30 min, was followed by an immediate fall by 20% FEV1. Simultaneously, a significant increase in bronchial hyperresponsiveness was demonstrated.

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