We present a rare case of propofol-induced acute necrotising pancreatitis, which is to the best of our knowledge the first fatal case reported in an adult patient.

Methods & Materials: 214 dogs, a donkey and a horse were sampled, in June 2018, from three locations in the Kabylia region: Bouira, Tizi-Ouzou and Sétif. Sera were analyzed using rapid immunomigration test (Witness ® Leishmania, Zoetis, France) followed by immunofluorescence test (IFAT) with 1/50 as positivity threshold. Blood samples were analyzed by a real-time PCR pan-Leishmania designed system, targeting 28S rRNA gene followed by qPCR targeting L. infantum kDNA. All dogs were examined and classed into one of the clinical scores (CS), from CS0 to CS4, per the frequency of their clinical signs. Results: The total prevalence is of 34.5% (74/214) when at least one of the tests is positive. IFAT was more sensible and the prevalence collected scored a 31.8% (68/214), followed by Witness ® Leishmania (29.9%, 64/214) and PCR (4.7%, 10/214). All positive samples on Leishmania spp. PCR 28S rRNA were positives for kDNA L. infantum specific PCR. The donkey and the horse were, also, positives by the two PCR systems. The equids lived near Leishmania infected dogs. Each infected dog where diagnosed in different stages of the disease: 74.3% (55/74) had at least one clinical sign and 25.7% (19/74) were asymptomatics; 43.2% (32/74) had CS1, 21.6% (16/74) had CS2, 5.4% (4/74) had CS3 and 4% had CS4.Conclusion: Kabylia remains an active focus for CanL with a high prevalence; this epidemiological situation requires the implementation of a national program against this protozoosis. This study highlights, for the first time, L. infantum in equids from Algeria which suggests the possible involvement of these animals in the epidemiological chain of L. infantum in high-transmission areas. This preliminary study deserves further investigation due to the lack of equids.Purpose: To present a case of acute anteroseptal ST-elevation myocardial infarction in the West Nile virus (WNV) meningoencephalitis.

Toxic epidermal necrolysis (TEN) is a life-threatening mucocutaneous disease with high mortality. Dithiocarbamates (DTC) are organosulphur compounds widely used in agriculture, industry and households. We report a case of TEN after exposure to mancozeb in fungicide. A 48-year-old 75 kg b.w. man was admitted with fever and generalized skin/mucous lesions after application of fungicide in a home garden. The patient had necrotic desquamation of gastrointestinal/respiratory tract mucosa, ocular lesion and skin epidermolysis of 90% of body surface. The laboratory findings included elevation of inflammatory parameters, hyperglycaemia, increased urea, creatinine, liver enzymes, hypoalbuminemia and electrolyte disturbances. The treatment included supportive care, management of fluid/electrolyte requirements, analgesics and enteral nutrition. Skin lesions were treated with occlusive non-adhesive biological wound dressings. Due to the proof of Acinetobacter, Escherichia coli and Escherichia faecalis from skin swabs, a combination of meropenem with amikacin was administered. During the next 2 weeks, complete re-epithelialization of skin lesions occurred, mucosal lesions healed and the laboratory parameters returned to normal. The patient was discharged on day 42. TEN is a rare condition that is generally caused by medications. Nevertheless, high attention should be paid to the cases of occupational or household exposure to DTC fungicides widely used in agriculture and home gardens because of their ability to cause TEN after skin and inhalation exposure. Greater emphasis on the hazardous properties of these products is necessary to ensure non-professional users are aware of the necessity of protective clothing during mixing, loading, application and early re-entry into treated fields.Toxic epidermal necrolysis (TEN), or Lyell's syndrome, is an acute life-threatening mucocutaneous disease with an epidermal loss of more than 30% of the body surface area and the involvement of at least two mucosal surfaces comprising ocular, oral and genital [1,2]. It is a rare condition with an incidence of 0.4-1.2 cases per million persons per year, but with a high mortality rate of 30-50% [3][4][5]. The morbidity and mortality result not only from the extensive denuded skin areas but also from the visceral involvement -particularly in the gastrointestinal and respiratory systems -sepsis, and multiple organ failure [6].The mechanism of TEN is not fully understood, but it appears to be the activation of autoimmune hypersensitivity reaction by the causative agents or their metabolites, as rechallenging an individual with the same agent can result in rapid recurrence of TEN [7,8]. The histopathology of skin lesions shows that keratinocyte apoptosis followed by necrosis is the pathogenic basis of the widespread epidermal detachment observed in TEN [9].Medications are the most frequent triggers of TEN, and more than 100 drugs have been implicated, including antibacterial sulphonamides, aromatic anticonvulsants, allopurinol, oxicam nonst...