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Glucagon was administered to six patients with acute myocardial infarction. Three of them had cardiogenic shock syndrome. Glucagon produced a positive inotropic response in all cases, which resulted in a significant rise in blood pressure, with only slight chronotropic effect. No arrhythmias were induced, and all patients with cardiogenic shock improved temporarily. Further evaluation of glucagon in shock syndrome to determine the dose and method of administration is required.

SUMMARY The rate of removal of a standard dose of 25 mg indocyanine green was studied in 67 patients at the bedside using dichromatic ear densitometry. The determination of the percentage disappearance rate per minute and the half life of the dye permitted separation of patients into three groups: those with normal liver function, those with liver damage, and a group taking opiates (9), anticonvulsants (8), phenylbutazone (2), haloperidol (1), and nitrofurantoin (1). The last group showed enhanced clearance of indocyanine green from the circulation.The dye indocyanine green has been shown to be an excellent agent for studying hepatic function (Fox,

21cimetidine treatment, and this appearance was not seen in any other case. We are not aware of any similar report.The meaning of our findings is not clear. Cimetidine may arrest bleeding from gastric erosions3 but has not been shown to heal such lesions, and their natural history is still not understood. It is therefore of great interest, if this agent really is responsible for stopping bleeding from gastric erosions, that bleeding erosive gastritis should occur during continuous cimetidine treatment.

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