Metastatic lesions in the breast from malignant diseases originated in other primary sources are rare. Mostly arise from the contra-lateral breast. The incidence extramammary origin of the breast metastasis is 1.2-2%. The usual extra-mammary primary sites of metastasis are malignant melanoma, lung cancer and Non-Hodgkin lymphoma. In any patient who has been diagnosed with a known primary cancer, if presented with a breast lump, a metastatic breast focus should be considered. The malignant melanoma [MM] characterised by widespread dissemination but infrequently metastasizes to the breast. In this paper we report a case of 43years old female with malignant melanoma with breast metastases. Staging CT chest & abdomen, showed bilateral lung nodules and numerous subcutaneous nodules, the largest seen in the umbilical area (Figure 4). Histology of the right breast biopsy reported staining for Melan-A & HMB45 is positive ( Figures 5A-5D). No staining for Cam5.2, ER, PR, CK7 and CK20. Ki67 is 10%. Appearances and immuno-profile are consistent with metastatic malignant melanoma. Due to disease dissemination, the patient has been referred to palliative oncological treatment. DiscussionBreast melanoma could arise basically in the breast skin, primarily in breast parenchyma, metastases to breast tissue, in-transit metastases (IMs) to breast glandular tissue or metastases to the breast skin. Metastatic breast lesions might be the first presentation clinical sign of the primary malignancy.7 Breast metastatic lesions from extramammary origin are uncommon. They encounter only 2% of total breast tumours. 8The top three sites are the contra-lateral breast, lymphomas and disseminated melanoma. Other sites are ovarian, lung, and gastric malignancies in addition to carcinoids & rhabdomyosarcomas.

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