For epididymitis in men over the age of 40 years ciprofloxacin 500 mg orally twice daily is more effective than pivampicillin 700 mg orally twice daily. Furthermore, ciprofloxacin has a lower incidence of adverse events.

Data from 4 separate beef cattle feedlot experiments, which were conducted at the Southeast Colorado Research Center (SECRC) in Lamar, CO, in 2001, 2003, 2004, and 2007, were utilized in a retrospective longitudinal study investigating possible relationships between daily water consumption (WC), DMI, and weather variables. The data set consisted of 8,209 records from 2001, 2003, 2004, and 2007, with pen based daily WC (L•animal(-1)) and DMI measurements and calculated daily steer BW from April to October in each year. Daily weather data were obtained from the weather station located at Lamar Municipal Airport located approximately 1.9 km from SECRC. Data collected consisted of daily high, low, and mean temperature; high, low, and mean humidity; high, low, and mean sea level pressure; mean wind speed; total precipitation; and average daily wind direction (cosine of radians from due north). Univariate analysis demonstrated that the continuous variables of BW, humidity, and sea level pressure were negatively related (P < 0.0001), whereas DMI, temperature the previous day, daily temperature, change in temperature from the previous day, average wind speed, and the temperature-humidity index (THI) were positively related (P < 0.001) to daily WC. There was a trend (P < 0.06) for the cosine of wind direction (1 = due north and -1 = due south) to be negatively related to WC. The multivariate, parsimonious model predicting average daily WC included (P < 0.05) average humidity, average humidity squared, high temperature squared, high humidity squared, low temperature, low temperature squared, low humidity, average sea level pressure, average wind speed, average daily BW, high sea level pressure, low sea level pressure, high humidity, and low humidity. The generalized R(2) of the parsimonious multivariate model was 0.32. These results indicate that BW and numerous weather factors are related to WC by yearling feedlot steers. Dry matter intake had minimal impact on WC for yearling feedlot steers consuming steam-flaked corn-based high concentrate diets from mid-spring to early fall.

This systematic review demonstrates adherence reporting in clinical trials of oral anticancer agents is infrequent. When reported, adherence was not associated with overall study quality or other study characteristics. Given the potential effects of non-adherence on study power and validity, adherence reporting should be encouraged in oncology and hematology clinical trials.

19558 Introduction: Osteoporotic fracture represents a major source of morbidity in PmW. Breast cancer patients can be at additional risk because of treatment related estrogen deprivation. The favorable effects of bisphosphonates in osteoporosis and potential reduction of metastases warrant evaluation of ZA in PmW at high risk for breast cancer relapse. We assessed whether ZA 4 mg IV every 12 weeks x 4 doses was associated with an increase in BMD. Secondary objectives included defining ZA’s toxicity profile in this setting, and assessing for differences in overall cancer relapse. Methods: PmW with node positive or stage III breast cancer diagnosed less than 5 years earlier were randomized to ZA or observation. BMD was assessed by dual energy xray absorptiometry (DXA) for all subjects at 0 and 12 months. A toxicity evaluation was performed pre- and post-treatment for patients receiving ZA. Study endpoint occurred when subjects completed the DXAs, had disease progression or declined further treatment. We calculated change in BMD between 0 and 12 months at the L1–4 spine and femur neck. Results: 66 women have enrolled since 2000; 49 women have completed DXAs at 0 and 12 months (observation 23, ZA 26). Median age was 52 (range 40–81 yr), median ECOG performance status was 0 (range 0–1), and most women received concurrent tamoxifen (observation 74%, ZA 61%). Over 12 months, L1–4 spine BMD decreased in the observation arm (-0.006 ± 0.034 g/cm2) and increased in the ZA arm (p<0.001; 0.050 ± 0.042 g/cm2). No significant BMD change occurred at the femur neck. Only three grade 3 events occurred (2 arthralgia, 1 myalgia). Side effects were mild and transient, but as frequent as 87% following dose 1. The most common side effects were fatigue, myalgia and arthralgia. No clinically significant changes in creatinine or calcium occurred. Osteonecrosis of the jaw was not observed. Of the 66 women enrolled, 7 have relapsed (observation 4, ZA 3) but time since diagnosis is less than 10 years for most patients. Conclusions: ZA administered every 12 weeks for 4 doses leads to a statistically and clinically significant change in BMD at the lumbar spine. Toxicity was mild but common. There are as yet no significant differences in cancer relapse. No significant financial relationships to disclose.