Abstract-A detailed characterization of the room temperature fatigue properties of powder metallurgical Mo, M+W and Ti-Zr-Mo (TZM) alloys is presented. In particular the factors affecting fatigue crack nucleation and growth behaviour are described. Fatigue tests were carried out by conventional rotating-bending and compared with results from a time-saving 20 kHz resonance push-pull test method. Fatigue strength data were determined by a statistical evaluation of test results from a sufficiently large number of specimens. The results show an increase in fatigue strength with alloying additions. Fatigue cracks were observed nucleating at highly localized slip bands at the specimen surface with the fatigue crack zones comprising only a small fraction of the total specimen cross-section. Fatigue crack growth rates at low stress intensities and threshold stress intensity values for crack growth were determined for a stress ratio of R = -1 using a 20 kHz resonance test method. These latter values were found to be sensitively dependent on microstructure, composition and processing history.