In this article, polystyrylpyridines (PSP resins) are presented. A discussion on the chemical aspects introduces these materials; then in the first part of the article, synthesis and processing of PSP resins are introduced. In particular, PSP prepolymers are obtained by heating nearly equimolecular mixtures of terephtaldialdehyde and sym‐collidine in the presence of an acidic catalyst. However, to improve the performance or processing conditions, several modifications have been brought to the standard collidine‐terephtaldialdehyde composition, and some examples of modified styrylpyridine resin are presented in the aricle. In the second part of the article, uses and applications as matrices for composites are discussed. In particular, some commercially available resin are introduced, and finally, a discussion on economic aspects and safety factors of their uses is reported.